Pharmacologic regulation of the early steps of purine biosynthesis in Burkitt lymphoma cells and in Ehrlich ascites tumor cells.
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چکیده
منابع مشابه
Investigating the anti-tumoral effect of curcumin on the mice in which Ehrlich ascites and solid tumor is created
Objective(s): In this study, the effects of different doses of curcumin application on Ehrlich ascites tumor (EAT) created in the mice of BALB/c type were investigated.Materials and Methods: Curcumin extracts can have hindering effect on tumor volume, vascular density, EAT cells around the tissues, and can support apoptosis. EAT cells (1x106) received from stock animals were injected intraperit...
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The antitumor activity of ethanol extract of Prosopis glandulosa Torr. (EPG) was evaluated against Ehrlich ascites carcinoma (EAC) tumor model in Swiss albino mice on dose dependent manner. The activity was assessed using survival time, average increase in body weight, hematological parameters and solid tumor volume. Oral administration of EPG at the dose of 100, 200 and 400 mg/Kg, significantl...
متن کاملInhibition of Furine Nucleotide Metabolism by 6-Methylthiopurine Ribonucleoside and Structurally Related Compounds1
6-Methylthiopurine ribonucleoside was found to inhibit nucleotide formation from hypoxanthine and aminoimidazole carboxamide in Ehrlich ascites tumor cells in vitro and to inhibit inosinate dehydrogenase activity in intact cells. These effects are produced at higher drug concentrations than required to inhibit purine biosynthesis de novo. 4-Methylthio-7-|8-D-ribofuranosyl pyrrolo[2,3-i/]pyrimid...
متن کاملPseudofeedback Inhibition of Purine Synthesis by 6-mercaptopurine Ribonucleotide and Other Purine Analogues.
Exogenous purines are known to suppress purine synthesis de novo in bacteria (2-4), HeLa and L cells (5), and ascites cells (6) growing in culture. High levels of purines, especially adenine, inhibit accumulation of late purine precursors in the media of bacteria with blocks in the pathway of purine synthesis (2, 3), or of formylglycinamide ribonucleotide in Ehrlich ascites cells grown in the p...
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ورودعنوان ژورنال:
- The Journal of pharmacology and experimental therapeutics
دوره 191 1 شماره
صفحات -
تاریخ انتشار 1974